Product Name：(2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide Usage: Deutetrabenazine intermediate Chemical Name: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide;2-acetyl-N,N,N,4-tetraMethylpentan-1-aMiniuM iodide Cas No.: 1069-62-1
Usage: Deutetrabenazine intermediate
Chemical Name: (2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide;2-acetyl-N,N,N,4-tetraMethylpentan-1-aMiniuM iodide
Cas No.: 1069-62-1
Molecular Formula: C11H24INO
Molecular Weight: 313.2
Specifications:
Appearance: white crystalline to off- white solid
Purity: 99.0%min
Expand Information:
Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated Tetrabenazine. The presence of deuterium in deutetrabenazine increases the half-lives of the active metabolite and prolongs their pharmacological activity by attenuating CYP2D6 metabolism of the compound. This allows less frequent dosing and a lower daily dose with improvement in tolerability. Decreased plasma fluctuations of deutetrabenazine due to attenuated metabolism may explain a lower incidence of adverse reactions associated with deutetrabenazine. Deutetrabenazine is a racemic mixture containing RR-Deutetrabenazine and SS-Deutetrabenazine.
