Product Name：2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid Usage: Alectinib Intermediate. Treatment of advanced ALK-positive non-small cell lung cancer. Chemical Name: 4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid Cas No.: 1256584-73-2
Usage: Alectinib Intermediate.Treatment of advanced ALK-positive non-small cell lung cancer.
Chemical Name: 4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid
Cas No.: 1256584-73-2
Molecular Formula: C12H15IO2
Molecular Weight: 318.2
Specifications:
Appearance: off-white to White powder,
Purity: 98.0%min
Expand Information:
Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting in reduced tumour cell viability.
