2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic Acid/1256584-73-2

Product Name:2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
Usage: Alectinib Intermediate. Treatment of advanced ALK-positive non-small cell lung cancer.
Chemical Name: 4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid
Cas No.: 1256584-73-2

Product Details

Product Name:2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

Usage:   Alectinib Intermediate.Treatment of advanced ALK-positive non-small cell lung cancer.

Chemical Name: 4-Ethyl-3-iodo-α,α-dimethylbenzeneacetic acid

Cas No.: 1256584-73-2


Molecular Formula: C12H15IO2
Molecular Weight: 318.2


Specifications: 

Appearance: off-white to White powder,

Purity: 98.0%min


Expand Information:

Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK prevents phosphorylation and subsequent downstream activation of STAT3 and AKT resulting in reduced tumour cell viability.


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